Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

Base Information

Chemical Name:Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate
CAS No.:286377-21-7
Molecular Formula:C₁₂H₁₂BrNO₇
Molecular Weight:362.134
Hs Code.:

Synonyms:Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

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Chemical Property of Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

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Technology Process of Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

There total 4 articles about Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 105-36-2
ethyl bromoacetate

: 1027055-80-6
5-Bromo-2-hydroxy-4-nitrobenzoic acid methyl ester

: 286377-21-7
Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

Guidance literature:: With potassium carbonate; In acetone; for 12h; Heating;
DOI:10.1055/s-2000-6396

Reference yield:

: 35290-97-2
4-amino 5-bromo 2-methoxy benzoic acid

: 286377-21-7
Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂; H₂O; HBF₄ / 0.5 h / 0 °C

1.2: 75 percent / Cu; NaNO₂ / H₂O / 3 h / 20 °C

2.1: 97 percent / HBr; AcOH; Ac₂O / 6 h / Heating

3.1: 85 percent / H₂SO₄ / 24 h / Heating

4.1: 98 percent / K₂CO₃ / acetone / 12 h / Heating

With tetrafluoroboric acid; sulfuric acid; water; hydrogen bromide; acetic anhydride; potassium carbonate; acetic acid; sodium nitrite; In acetone; 1.1: Diazotization / 1.2: Substitution / 2.1: ether cleavage / 3.1: Esterification / 4.1: Alkylation;
DOI:10.1055/s-2000-6396

Reference yield:

: 286377-19-3
5-Bromo-2-hydroxy-4-nitrobenzoic acid

: 286377-21-7
Ethyl 4-bromo-2-(methoxycarbonyl)-5-nitrophenoxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂SO₄ / 24 h / Heating

2: 98 percent / K₂CO₃ / acetone / 12 h / Heating

With sulfuric acid; potassium carbonate; In acetone; 1: Esterification / 2: Alkylation;
DOI:10.1055/s-2000-6396