(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

Base Information

Chemical Name:(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane
CAS No.:1234156-14-9
Molecular Formula:C₁₈H₂₈O₃Si
Molecular Weight:320.504
Hs Code.:

Synonyms:(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

Suppliers and Price of (1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

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Technology Process of (1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

There total 1 articles about (1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127379-33-3
trans-3-Hydroxy-1,2-epoxycyclohexan

: 80180-46-7
1-<(tert-butyldimethylsilyl)oxy>-2-hydroxybenzene

: 1234156-14-9
(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

Guidance literature:: 1-<(tert-butyldimethylsilyl)oxy>-2-hydroxybenzene; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; Cooling with ice;

trans-3-Hydroxy-1,2-epoxycyclohexan; In tetrahydrofuran; at 20 ℃; optical yield given as %ee; Cooling with ice;
DOI:10.1021/ja1035286

Reference yield: 17.0%

: 67-56-1
methanol

: 7677-24-9
trimethylsilyl cyanide

: 1234156-14-9
(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

: 1234156-16-1
(1R,2R,3R)-3-(2'-t-butyldimethylsilyloxyphenoxy)-2-hydroxycyclohexanecarbonitrile

: 1234156-15-0
(1R,2R,6S)-6-methoxycarbonyl-2-(2'-t-butyldimethylsilyloxyphenoxy)cyclohexanol

Guidance literature:: trimethylsilyl cyanide; (1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane; With gadolinium(III) isopropoxide; In tetrahydrofuran; at 20 - 50 ℃;

With water; In tetrahydrofuran; at 100 ℃; for 1.5h;

methanol; optical yield given as %ee; Further stages;
DOI:10.1021/ja1035286

Reference yield:

: 101-81-5
Diphenylmethane

: 1234156-14-9
(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane

: C₃₁H₄₀O₃Si

Guidance literature:: Diphenylmethane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

(1R,2R,6R)-2-(2'-t-butyldimethylsilyloxyphenoxy)-7-oxabicyclo[4.1.0]heptane; In tetrahydrofuran; hexane; at 20 ℃; for 0.166667h;

With water; ammonium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja1035286