(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

Base Information

Chemical Name:(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol
CAS No.:212266-69-8
Molecular Formula:C₂₆H₃₁NO₅S
Molecular Weight:469.602
Hs Code.:

Synonyms:(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

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Technology Process of (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

There total 9 articles about (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 212266-68-7
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine

: 212266-69-8
(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01171-X

Reference yield:

: 100-39-0
benzyl bromide

: 212266-69-8
(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 1.) NaH, 2.) n-Bu₄NI / tetrahydrofuran / 24 h / 0 °C

2: 95 percent / 3M HCl / ethyl acetate / 1 h / Ambient temperature

3: 97 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / Ambient temperature

4: 94 percent / 4M HCl / tetrahydrofuran / 3 h / Ambient temperature

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; sodium hydride; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(98)01171-X

Reference yield:

: 116611-44-0
((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester

: 212266-69-8
(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 1.) NaH, 2.) n-Bu₄NI / tetrahydrofuran / 24 h / 0 °C

2: 95 percent / 3M HCl / ethyl acetate / 1 h / Ambient temperature

3: 97 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / Ambient temperature

4: 94 percent / 4M HCl / tetrahydrofuran / 3 h / Ambient temperature

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; sodium hydride; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(98)01171-X