212266-68-7Relevant articles and documents
Asymmetric synthesis of 4-substituted prolines as conformationally constrained amino acid analogues
Wang, Qian,Sasaki, N. Andre,Potier, Pierre
, p. 15759 - 15780 (2007/10/03)
Treatment of readily available chiral building block 1 with (2R)-2,3-O- isopropylideneglyceraldehyde (5) provides a new route for asymmetric synthesis of 2,4-disubstituted pyrrolidines. Several proline-amino acid chimeras: proline-leucine, proline-lysine, proline-arginine and proline- glutamic acid, are synthesized in highly diastereomerically pure forms.