2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide

Base Information

• Chemical Name: 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide
• CAS No.: 35624-81-8
• Molecular Formula: C₁₇H₁₇NO₄S
• Molecular Weight: 331.392

Synonyms:2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide

Chemical Property of 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide

Chemical Property:

Purity/Quality:

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Technology Process of 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide

There total 4 articles about 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide (5510-31-6) + benzyl bromide (100-39-0) → 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide (35624-81-8)

Guidance literature:

DOI:10.1021/jm00294a008

Reference yield:

1,1-dioxo-2-(2-oxo-propyl)-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (40506-05-6) → 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide (35624-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaOEt; EtOH / 0.5 h / 55 °C

1.2: aq. HCl / 0.5 h / 20 °C

2.1: p-TsOH / benzene / 2 h / Heating

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: dimethylformamide / 20 °C

With ethanol; sodium ethanolate; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0960-894X(03)00484-0

Reference yield:

saccharin (81-07-2) → 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide (35624-81-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aq. NaOH / 1 h / 20 °C

1.2: cetyl trimethylammonium bromide / toluene / Heating

2.1: NaOEt; EtOH / 0.5 h / 55 °C

2.2: aq. HCl / 0.5 h / 20 °C

3.1: p-TsOH / benzene / 2 h / Heating

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: dimethylformamide / 20 °C

With sodium hydroxide; ethanol; sodium ethanolate; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0960-894X(03)00484-0

upstream raw materials:

2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide

benzyl bromide

1,1-dioxo-2-(2-oxo-propyl)-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

saccharin

Downstream raw materials:

2-benzyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[e][1,2]thiazin-4-one

1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-3-carboxylic acid anilide

2-benzyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-3-carboxylic acid anilide

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