(2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester

Base Information

• Chemical Name: (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester
• CAS No.: 128368-44-5
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Mol file: 128368-44-5.mol

Synonyms:(2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester

Chemical Property of (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester

There total 7 articles about (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-isopropenyl-4-methoxyaniline (128368-43-4) + methyl chloroformate (79-22-1) → (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester (128368-44-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.3987/COM-12-12599

Reference yield:

tert-butyl (2-iodo-4-methoxyphenyl)carbamate (157496-75-8) → (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester (128368-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / Reflux

2: trifluoroacetic acid / dichloromethane / 20 °C

3: potassium carbonate / tetrahydrofuran / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.3987/COM-12-12599

Reference yield:

C15H21NO3 (1426832-63-4) → (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester (128368-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

With potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.3987/COM-12-12599

upstream raw materials:

2-isopropenyl-4-methoxyaniline

methyl chloroformate

1-(2-amino-5-methoxy-phenyl)-ethanone

2-(2-amino-5-methoxyphenyl)propan-2-ol

Downstream raw materials:

(±)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole

[(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid

[(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid methyl ester