ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

Base Information

Chemical Name:ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride
CAS No.:149690-13-1
Molecular Formula:C₂₀H₂₅NO₂*ClH
Molecular Weight:347.885
Hs Code.:

Synonyms:ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

Suppliers and Price of ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

There total 1 articles about ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-5-([1,1`-biphenyl]-4-yl)-2-methyl-4-pentanone ethyl ester

: 149690-13-1
ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

: 149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

: (2S,4R)-4-amino-5-(1,1'-biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride

: ethyl (2R,4R)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

Guidance literature:: (R)-5-([1,1`-biphenyl]-4-yl)-2-methyl-4-pentanone ethyl ester; With titanium(IV) tetraethanolate; In tetrahydrofuran; for 12h; Reflux;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In ethanol; water; at 120 ℃; for 0.5h; Overall yield = 19.9 %; Overall yield = 20 mg; Microwave irradiation;

Reference yield: 78.0%

: 108-30-5
succinic acid anhydride

: 149690-13-1
ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

: 108-91-8,157973-60-9
cyclohexylamine

: 149709-63-7,766480-48-2
α-ethyl (αS,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate

Guidance literature:: succinic acid anhydride; ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 18h;

cyclohexylamine; In ethyl acetate; at 40 - 65 ℃;
DOI:10.1021/acs.oprd.8b00350

Reference yield:

: 149690-13-1
ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

: 149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

: 1038925-00-6
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

: 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Guidance literature:: ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride; With triethylamine; In Isopropyl acetate; at 55 ℃; for 1h;

In Isopropyl acetate; for 24h; Product distribution / selectivity; Heating / reflux;