2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

Base Information

Chemical Name:2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione
CAS No.:1425942-97-7
Molecular Formula:C₂₆H₁₇Cl₃F₃NO₄
Molecular Weight:570.779
Hs Code.:

Synonyms:2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

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Chemical Property of 2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

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Technology Process of 2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

There total 3 articles about 2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 201230-82-2
carbon monoxide

: 1425942-96-6
2-[[2-chloro-4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxy-but-1-enyl]phenyl]methyl]isoindoline-1,3-dione

: 1425942-97-7
2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

Guidance literature:: With dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; In tetrahydrofuran; at 100 ℃; for 36h; under 37503.8 Torr; Inert atmosphere;

Reference yield:

: 1425942-93-3
2-(3,5-dichlorophenyl)-1,1,1-trifluoro-but-3-en-2-ol

: 1425942-97-7
2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate / N,N-dimethyl acetamide / 72 h / 130 °C / Inert atmosphere

2: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / tetrahydrofuran / 36 h / 100 °C / 37503.8 Torr / Inert atmosphere

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; sodium acetate; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1425942-97-7
2-[[2-chloro-4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]phenyl]methyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -75 - 20 °C

2: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate / N,N-dimethyl acetamide / 72 h / 130 °C / Inert atmosphere

3: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / tetrahydrofuran / 36 h / 100 °C / 37503.8 Torr / Inert atmosphere

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; sodium acetate; In tetrahydrofuran; N,N-dimethyl acetamide;