methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

Base Information

• Chemical Name: methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester
• CAS No.: 866456-98-6
• Molecular Formula: C₃₁H₄₂O₆S
• Molecular Weight: 542.737
• Mol file: 866456-98-6.mol

Synonyms:methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

Chemical Property of methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

There total 4 articles about methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol (866456-94-2) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester (866456-98-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol (866456-94-2) → methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester (866456-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / pyridine / 96 h / 20 °C

2: 65 percent / LiBEt₃H / tetrahydrofuran / Heating

3: 98 percent / CH₂Cl₂ / 3 h / 20 °C

With pyridine; lithium triethylborohydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester (866456-92-0) → methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester (866456-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 98 percent / CH₂Cl₂ / 3 h / 20 °C

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

DOI:10.1016/j.tetasy.2005.06.033

upstream raw materials:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol

methanesulfonyl chloride

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

4-methylbenzene-1-sulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

Downstream raw materials:

4-methylbenzene-1-sulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-iodo-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran