[2S-(2α(1R,2S),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester
CAS No.:866456-92-0
Molecular Formula:C₃₄H₄₆O₅
Molecular Weight:534.736
Hs Code.:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

Synonyms:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

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Chemical Property of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

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Technology Process of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

There total 1 articles about [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 866456-91-9
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

: 109-72-8,29786-93-4
n-butyllithium

: 74-88-4
methyl iodide

: (1R,2R,4R,6R,7R)-4-((S)-1,2-Diphenyl-ethoxy)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decane

: 866456-92-0
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

: 5-{1-[(1S,2R)-1,2-Diphenyl-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethoxy]-ethyl}-nonan-5-ol

Guidance literature:: [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -15 ℃; for 0.5h;

n-butyllithium; In tetrahydrofuran; at -60 - -20 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at -15 - 20 ℃;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield: 94.0%

: 866456-92-0
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

: 866456-94-2
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-92-0
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

: 866457-01-4
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 81 percent / I₂; PPh₃; imidazole / toluene / Heating

3: 98 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; lithium triethylborohydride; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; toluene;
DOI:10.1016/j.tetasy.2005.06.033