[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Base Information

• Chemical Name: [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran
• CAS No.: 866456-96-4
• Molecular Formula: C₃₁H₄₂O₄
• Molecular Weight: 478.672
• Mol file: 866456-96-4.mol

Synonyms:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Chemical Property of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

There total 4 articles about [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol (866456-94-2) + methyl iodide (74-88-4) → [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran (866456-96-4)

Guidance literature:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol; With sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at 20 ℃; for 1h;

methyl iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester (866456-98-6) → [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran (866456-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72 percent / LiBEt₃H / tetrahydrofuran / Heating

2.1: NaH / hexamethylphosphoric acid triamide; dimethylformamide / 1 h / 20 °C

2.2: 84 percent / dimethylformamide; hexamethylphosphoric acid triamide / 20 °C

With sodium hydride; lithium triethylborohydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester (866456-92-0) → [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran (866456-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 94 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2.1: NaH / hexamethylphosphoric acid triamide; dimethylformamide / 1 h / 20 °C

2.2: 84 percent / dimethylformamide; hexamethylphosphoric acid triamide / 20 °C

With lithium aluminium tetrahydride; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2005.06.033

upstream raw materials:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol

methyl iodide

methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

Downstream raw materials:

oxophenylacetic acid [1R,2S]-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethyl ester

(1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol