3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

Base Information

Chemical Name:3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine
CAS No.:389873-56-7
Molecular Formula:C₃₄H₄₈N₂O₅Si₂
Molecular Weight:620.937
Hs Code.:

Synonyms:3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

Suppliers and Price of 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

There total 1 articles about 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 162052-68-8
3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

: 389873-56-7
3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 25 ℃;
DOI:10.1002/1521-3773(20011001)40:19<3693::AID-ANIE3693>3.0.CO;2-O

Reference yield: 73.0%

: 389873-56-7
3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

: 607716-77-8
1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-vinyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -30 ℃;
DOI:10.1016/S0040-4039(03)01584-3

Reference yield:

: 389873-56-7
3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine

: 591754-20-0
5'-O-(4,4'-dimethoxysilyl)-4'-C-(ethyl)thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: nBu₄NF / tetrahydrofuran / 3 h / 20 °C

2: hydrogen / Pd/C (10percent) / methanol / 2 h

3: 76 percent / pyridine; 4-(dimethylamino)pyridine / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; hydrogen; Pd/C (10percent); In tetrahydrofuran; methanol;
DOI:10.1002/ejoc.200200641