(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

Base Information

Chemical Name:(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide
CAS No.:178871-92-6
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:

Synonyms:(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

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Chemical Property of (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

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Technology Process of (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

There total 4 articles about (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 192060-34-7
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide

: 178871-92-6
(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.33333h;

benzyl bromide; In tetrahydrofuran; hexane; at 0 ℃; Further stages.;
DOI:10.1055/s-2008-1000851

Reference yield: 30.0%

: potassium (S)-2-((trifluoroboryl)methyl)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,3-dimethylbutanamide

: 108-90-7
chlorobenzene

: 178871-92-6
(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

Guidance literature:: With palladium diacetate; potassium carbonate; ruphos; In water; toluene; at 85 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol101865e

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 178871-92-6
(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3,N-methylbutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent

2: 83 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 0 °C

With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja970402f