8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane
CAS No.:866615-16-9
Molecular Formula:C₁₈H₂₄F₃NO₂
Molecular Weight:343.389
Hs Code.:

Synonyms:8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

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Technology Process of 8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

There total 3 articles about 8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866615-10-3
4-fluoro-3-propoxybenzotrifluoride

: 120-29-6
3-tropanol

: 866615-16-9
8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 - 100 ℃;

Reference yield:

: 107-08-4
1-iodo-propane

: 120-29-6
3-tropanol

: 141483-15-0
2-fluoro-5-trifluoromethylphenol

: 866615-16-9
8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

Guidance literature:: 2-fluoro-5-trifluoromethylphenol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

1-iodo-propane; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

3-tropanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 - 100 ℃;

Reference yield:

: 141483-15-0
2-fluoro-5-trifluoromethylphenol

: 866615-16-9
8-methyl-3α-[2-propoxy-4-(trifluoromethyl)phenoxy]-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Cooling with ice

1.2: 0.5 h / 90 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 100 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;