(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

Base Information

Chemical Name:(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester
CAS No.:207985-93-1
Molecular Formula:C₄₀H₆₇N₄O₁₂P
Molecular Weight:826.965
Hs Code.:

(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

Synonyms:(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

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Chemical Property of (S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

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Technology Process of (S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

There total 11 articles about (S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 207985-93-1
(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 69 percent / iPr₂NEt / dimethylformamide

2: Et₃N / CH₂Cl₂ / 0 - 25 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2 h

4: EDC, HOBt / dimethylformamide; ethyl acetate / 16 h / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

6: 73 percent / EDC, HOBt / dimethylformamide / 12 h / 0 °C

7: H₂ / 10percent Pd/C / ethyl acetate

8: EDC / dimethylformamide

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja973713z

Reference yield:

: 128948-78-7
methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

: 207985-93-1
(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / 0 °C

2: Et₃N / CH₂Cl₂ / 0 - 25 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2 h

4: EDC, HOBt / dimethylformamide; ethyl acetate / 16 h / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

6: 73 percent / EDC, HOBt / dimethylformamide / 12 h / 0 °C

7: H₂ / 10percent Pd/C / ethyl acetate

8: EDC / dimethylformamide

With thionyl chloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja973713z

Reference yield:

: 90763-55-6
C₁₄H₂₁ClNO₄P

: 207985-93-1
(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 0 - 25 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 2 h

3: EDC, HOBt / dimethylformamide; ethyl acetate / 16 h / Ambient temperature

4: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

5: 73 percent / EDC, HOBt / dimethylformamide / 12 h / 0 °C

6: H₂ / 10percent Pd/C / ethyl acetate

7: EDC / dimethylformamide

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja973713z