methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

Base Information

• Chemical Name: methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate
• CAS No.: 128948-78-7
• Molecular Formula: C₁₄H₂₂NO₅P
• Molecular Weight: 315.306
• Mol file: 128948-78-7.mol

Synonyms:methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

Chemical Property of methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

There total 4 articles about methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-benzyl N-[1-(dimethoxyphosphoryl)-3-methylbutyl]carbamate (128948-79-8) → methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate (128948-78-7)

Guidance literature:

With sodium hydroxide; In methanol; at 21 ℃; for 12h;

DOI:10.1021/jo00313a012

Reference yield:

<(1R)-1-amino>-3-methylbutyl>phosphonic acid (128948-77-6) → methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate (128948-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 9 h / 110 °C

2: 95 percent / 2 N NaOH / methanol / 12 h / 21 °C

With sodium hydroxide; In methanol;

DOI:10.1021/jo00313a012

Reference yield:

L-Leucine phosphonate (88081-77-0) → methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate (128948-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaHCO₃, Na₂CO₃, 2 N NaOH / H₂O / Ambient temperature

2: 95 percent / 9 h / 110 °C

3: 95 percent / 2 N NaOH / methanol / 12 h / 21 °C

With sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; In methanol; water;

DOI:10.1021/jo00313a012

upstream raw materials:

(R)-benzyl N-[1-(dimethoxyphosphoryl)-3-methylbutyl]carbamate

<(1R)-1-amino>-3-methylbutyl>phosphonic acid

L-Leucine phosphonate

benzyl chloroformate

Downstream raw materials:

C₁₇H₂₇N₂O₅P

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid ethyl ester

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid tert-butyl ester