(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

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Chemical Name:(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid
CAS No.:207985-94-2
Molecular Formula:C₃₁H₅₁N₄O₁₀P
Molecular Weight:670.74
Hs Code.:

(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

Synonyms:(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

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Chemical Property of (S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

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Technology Process of (S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

There total 11 articles about (S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 207985-93-1
(S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester

: 207985-94-2
(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

Guidance literature:: With dimethylsulfide; trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1021/ja973713z

Reference yield:

: 128948-78-7
methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

: 207985-94-2
(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

Guidance literature:: Multi-step reaction with 9 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / 0 °C

2: Et₃N / CH₂Cl₂ / 0 - 25 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2 h

4: EDC, HOBt / dimethylformamide; ethyl acetate / 16 h / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

6: 73 percent / EDC, HOBt / dimethylformamide / 12 h / 0 °C

7: H₂ / 10percent Pd/C / ethyl acetate

8: EDC / dimethylformamide

9: 88 percent / TFA, Me₂S / CH₂Cl₂ / 0.5 h

With thionyl chloride; dimethylsulfide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja973713z

Reference yield:

: 90763-55-6
C₁₄H₂₁ClNO₄P

: 207985-94-2
(S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / 0 - 25 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 2 h

3: EDC, HOBt / dimethylformamide; ethyl acetate / 16 h / Ambient temperature

4: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

5: 73 percent / EDC, HOBt / dimethylformamide / 12 h / 0 °C

6: H₂ / 10percent Pd/C / ethyl acetate

7: EDC / dimethylformamide

8: 88 percent / TFA, Me₂S / CH₂Cl₂ / 0.5 h

With dimethylsulfide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja973713z