Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

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Chemical Name:Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester
CAS No.:201735-93-5
Molecular Formula:C₄₈H₅₄N₆O₁₂
Molecular Weight:906.99
Hs Code.:

Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

Synonyms:Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

Suppliers and Price of Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

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Chemical Property of Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

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Technology Process of Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

There total 10 articles about Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 201735-92-4
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

: 1-(5-O-benzyloxycarbonyl-3-aza-pentyl)-N³-benzoyl thymine hydrochloride

: 201735-93-5
Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 24h; other reagents: 1,3-dicyclohexylcarbodiimide/triethylamine, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, bromo-tris-pyrrolidino-phosphonium hexafluorophosphate;
DOI:10.1016/S0960-894X(97)10172-X

Reference yield: 29.0%

: 538-75-0
dicyclohexyl-carbodiimide

: 201735-92-4
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

: C₃₇H₅₃N₅O₇

: 201735-93-5
Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

Guidance literature:: With triethylamine; 1-(5-O-benzyloxycarbonyl-3-aza-pentyl)-N³-benzoyl thymine hydrochloride;
DOI:10.1016/S0960-894X(97)10172-X

Reference yield:

: 201735-89-9
benzyl N-tert-butoxycarbonyl-N-(2-hydroxyethyl)-5-aminopentanoate

: 201735-93-5
Carbonic acid 2-[[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-(5-{[2-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoyl)-amino]-ethyl ester benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ph₃P; diethylazodicarboxylate / tetrahydrofuran / 2.5 h / 20 °C

2: 90 percent / H₂ / Pd(OH)2/C / tetrahydrofuran / 18 h

3: 67 percent / i-Pr₂EtN; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyl uronium BF₄^(1-) / acetonitrile / 24 h / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1081/NCN-120003176