5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

Base Information

Chemical Name:5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid
CAS No.:201735-92-4
Molecular Formula:C₂₄H₃₁N₃O₇
Molecular Weight:473.526
Hs Code.:

Synonyms:5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

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Chemical Property of 5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

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Technology Process of 5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

There total 9 articles about 5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 201735-90-2
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid benzyl ester

: 201735-92-4
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In tetrahydrofuran; for 24h; under 760 Torr; Ambient temperature;
DOI:10.1016/S0960-894X(97)10172-X

Reference yield:

: 201735-89-9
benzyl N-tert-butoxycarbonyl-N-(2-hydroxyethyl)-5-aminopentanoate

: 201735-92-4
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Ph₃P; diethylazodicarboxylate / tetrahydrofuran / 2.5 h / 20 °C

2: 90 percent / H₂ / Pd(OH)2/C / tetrahydrofuran / 18 h

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; 1: Mitsunobu reaction;
DOI:10.1081/NCN-120003176

Reference yield:

: 201735-88-8
benzyl N-allyl-N-tert-butoxycarbonyl-5-aminopentanoate

: 201735-92-4
5-{[2-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tert-butoxycarbonyl-amino}-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / CH₂Cl₂; tetrahydrofuran / 0.75 h / -78 °C

1.2: 79 percent / NaBH₄ / CH₂Cl₂; tetrahydrofuran / -78 - 20 °C

2.1: 85 percent / Ph₃P; diethylazodicarboxylate / tetrahydrofuran / 2.5 h / 20 °C

3.1: 90 percent / H₂ / Pd(OH)2/C / tetrahydrofuran / 18 h

With hydrogen; ozone; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1081/NCN-120003176