6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

Base Information

Chemical Name:6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester
CAS No.:918797-30-5
Molecular Formula:C₅₂H₈₂N₆O₁₁
Molecular Weight:967.257
Hs Code.:

6-<i>tert</i>-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

Synonyms:6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

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Chemical Property of 6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

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Technology Process of 6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

There total 16 articles about 6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-6-tert-butoxycarbonylamino-hexanoic acid propyl ester

: 918797-30-5
6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

2: H₂ / Pd/C / methanol

3: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

4: H₂ / Pd/C / methanol

5: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: carboxybenzyl-L-lysine allyl ester

: 918797-30-5
6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: H₂ / Pd/C / methanol

3: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

4: H₂ / Pd/C / methanol

5: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

6: H₂ / Pd/C / methanol

7: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: 918797-43-0
(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylaminohexanoic acid allyl ester

: 918797-30-5
6-tert-butoxycarbonylamino-2-{2-[4-(4-{1-[1-(2-butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoylamino}-hexanoic acid propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol

2: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

3: H₂ / Pd/C / methanol

4: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

5: H₂ / Pd/C / methanol

6: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d