(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

Base Information

Chemical Name:(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol
CAS No.:925415-14-1
Molecular Formula:C₂₄H₄₀O₅
Molecular Weight:408.579
Hs Code.:

Synonyms:(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

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Chemical Property of (6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

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Technology Process of (6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

There total 7 articles about (6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925212-42-6
6-(3-hydroxymethyl-2,2,4-trimethyl-cyclohex-3-enyl)-6-(2-methoxy-ethoxymethoxy)-hex-4-en-1-ol

: 925415-14-1
(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 1.08 h / 0 - 20 °C

2: 50 mg / tetrahydrofuran / 1 h / 20 °C

With Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2006.10.058

Reference yield:

: 925212-69-7
acetic acid 5-[6-hydroxy-1-(2-methoxy-ethoxymethoxy)-hex-2-enyl]-2,6,6-trimethyl-cyclohex-1-enylmethyl ester

: 925415-14-1
(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / LiOH*H₂O / H₂O; methanol / 1 h / 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 1.08 h / 0 - 20 °C

3: 50 mg / tetrahydrofuran / 1 h / 20 °C

With lithium hydroxide; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.tet.2006.10.058

Reference yield:

: 925212-41-5
[5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate

: 925415-14-1
(6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / diisopropylethylamine; DMAP / CH₂Cl₂ / 14 h / 20 °C

2: 90 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

3: 85 percent / LiOH*H₂O / H₂O; methanol / 1 h / 20 °C

4: Dess-Martin periodinane / CH₂Cl₂ / 1.08 h / 0 - 20 °C

5: 50 mg / tetrahydrofuran / 1 h / 20 °C

With dmap; lithium hydroxide; tetrabutyl ammonium fluoride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.tet.2006.10.058