1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

Base Information

Chemical Name:1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate
CAS No.:1373958-10-1
Molecular Formula:C₂₃H₂₆O₇S
Molecular Weight:446.521
Hs Code.:

Synonyms:1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

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Chemical Property of 1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

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Technology Process of 1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

There total 9 articles about 1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345879-02-8
4-[2-(1-hydroxymethyl-cyclopropylmethoxy)-3,4-dimethoxyphenyl]indan-1-one

: 124-63-0
methanesulfonyl chloride

: 1373958-10-1
1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 5150-42-5
2,3-dimethoxyphenol

: 1373958-10-1
1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 - 25 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

5.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

7.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d₁ / 16 h / 20 °C

8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d₁; N,N-dimethyl-formamide;

Reference yield:

: 1345712-96-0
1-bromo-3,4-dimethoxy-2-methoxymethoxybenzene

: 1373958-10-1
1-((2,3-dimethoxy-6-(1-oxo-2,3-dihydro-1H-inden-4-yl)phenoxy)methyl)cyclopropylmethyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

3.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d₁ / 16 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d₁; N,N-dimethyl-formamide;