{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Base Information

Chemical Name:{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester
CAS No.:161196-65-2
Molecular Formula:C₂₆H₂₈ClN₃O₃
Molecular Weight:465.98
Hs Code.:

Synonyms:{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

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Chemical Property of {2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

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Technology Process of {2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

There total 11 articles about {2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 67-56-1
methanol

: 161196-64-1
4'-[1-(2-Butyl-4-chloro-5-[1,3]dithian-2-ylidenemethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

: 161196-65-2
{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: With hydrogenchloride; mercury dichloride; In water; for 17h; Heating;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 161196-65-2
{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 67 percent / hexamethylenetetramine / acetic acid; H₂O / 1 h / 120 °C

2: 1.) NaH; 2.) NaH, I₂ / 1.) DME, 0 degC; 2.) 25-40 degC

3: Li₂CO₃ / dimethylformamide / 16 h / 80 °C

4: NaBH₄ / methanol / 1 h / -10 °C

5: NaHTe / ethanol / 3 h / Ambient temperature

6: 1.) Im; 2.) NaBH₄, CaCl₂ / 1.) DMF, room t., 3 h; 2.) i-PrOH, room t., 22 h

7: 94 percent / Im / dimethylformamide / Ambient temperature

8: 69 percent / HCOOH-H₂O / tetrahydrofuran / 18 h / Ambient temperature

9: 96 percent / triethylamine, (COCl)2 / dimethylsulfoxide; CH₂Cl₂ / -78 °C

10: 56 percent / tetrahydrofuran / 0.5 h / -78 °C

11: 64 percent / HgCl₂, HCl / H₂O / 17 h / Heating

With hydrogenchloride; sodium tetrahydroborate; formic acid; oxalyl dichloride; sodium hydrogen telluride; hexamethylenetetramine; impramine; iodine; lithium carbonate; sodium hydride; triethylamine; calcium chloride; mercury dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 135689-93-9
4-(2-Cyanophenyl)benzaldehyde

: 161196-65-2
{2-Butyl-5-chloro-3-[1-(2'-cyano-biphenyl-4-yl)-3-hydroxy-propyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) NaH; 2.) NaH, I₂ / 1.) DME, 0 degC; 2.) 25-40 degC

2: Li₂CO₃ / dimethylformamide / 16 h / 80 °C

3: NaBH₄ / methanol / 1 h / -10 °C

4: NaHTe / ethanol / 3 h / Ambient temperature

5: 1.) Im; 2.) NaBH₄, CaCl₂ / 1.) DMF, room t., 3 h; 2.) i-PrOH, room t., 22 h

6: 94 percent / Im / dimethylformamide / Ambient temperature

7: 69 percent / HCOOH-H₂O / tetrahydrofuran / 18 h / Ambient temperature

8: 96 percent / triethylamine, (COCl)2 / dimethylsulfoxide; CH₂Cl₂ / -78 °C

9: 56 percent / tetrahydrofuran / 0.5 h / -78 °C

10: 64 percent / HgCl₂, HCl / H₂O / 17 h / Heating

With hydrogenchloride; sodium tetrahydroborate; formic acid; oxalyl dichloride; sodium hydrogen telluride; impramine; iodine; lithium carbonate; sodium hydride; triethylamine; calcium chloride; mercury dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9