(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

Base Information

Chemical Name:(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid
CAS No.:1309366-12-8
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

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Chemical Property of (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

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Technology Process of (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

There total 9 articles about (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309366-11-7
(E)-ethyl 3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylate

: 1309366-12-8
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

Guidance literature:: With water; In methanol; for 0.75h; Reflux;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1309366-12-8
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

3: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

5: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

6: water / methanol / 0.75 h / Reflux

With water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1309366-12-8
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

4: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

5: water / methanol / 0.75 h / Reflux

With water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;