(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

Base Information

Chemical Name:(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide
CAS No.:1309366-13-9
Molecular Formula:C₃₀H₃₆N₄O₂
Molecular Weight:484.641
Hs Code.:

Synonyms:(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

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Chemical Property of (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

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Technology Process of (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

There total 10 articles about (E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309366-12-8
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-2-methylacrylic acid

: 74-89-5
methylamine

: 1309366-13-9
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

Guidance literature:: With Knorr's reagent; In 1-methyl-pyrrolidin-2-one; ethanol; for 0.0833333h;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1309366-13-9
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

3: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

5: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

6: water / methanol / 0.75 h / Reflux

7: Knorr's reagent / 1-methyl-pyrrolidin-2-one; ethanol / 0.08 h

With water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1309366-13-9
(E)-3-(2-(tert-butylamino)-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

4: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

5: water / methanol / 0.75 h / Reflux

6: Knorr's reagent / 1-methyl-pyrrolidin-2-one; ethanol / 0.08 h

With water; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;