(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

Base Information

Chemical Name:(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine
CAS No.:331731-33-0
Molecular Formula:C₂₈H₃₃NO₇
Molecular Weight:495.573
Hs Code.:

Synonyms:(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

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Technology Process of (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

There total 6 articles about (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 331731-32-9
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

: 331731-33-0
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 20h;
DOI:10.1021/ja003835i

Reference yield:

: 296252-58-9
3-benzyloxy-5-methoxystyrene

: 331731-33-0
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / t-butyl hypochlorite; (DHQD)2PHAL; NaOH / K₂OsO₂(OH)4 / H₂O; propan-1-ol / 1 h / 25 °C

2: 95 percent / i-Pr₂NEt / CH₂Cl₂ / 20 h / 25 °C

With sodium hydroxide; tert-butylhypochlorite; 1,4-bis(9-O-dihydroquinidine)phthalazine; N-ethyl-N,N-diisopropylamine; potassium dioxotetrahydroxoosmate(VI); In propan-1-ol; dichloromethane; water; 1: Sharpless asymmetric aminohydroxylation;
DOI:10.1021/ja003835i

Reference yield:

: 57179-35-8
3-hydroxy-5-methoxybenzaldehyde

: 331731-33-0
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 87 percent / tetrahydrofuran / 2 h / -78 - 25 °C

3: 78 percent / t-butyl hypochlorite; (DHQD)2PHAL; NaOH / K₂OsO₂(OH)4 / H₂O; propan-1-ol / 1 h / 25 °C

4: 95 percent / i-Pr₂NEt / CH₂Cl₂ / 20 h / 25 °C

With sodium hydroxide; tert-butylhypochlorite; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; N-ethyl-N,N-diisopropylamine; potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; propan-1-ol; dichloromethane; water; N,N-dimethyl-formamide; 3: Sharpless asymmetric aminohydroxylation;
DOI:10.1021/ja003835i