3-benzyloxy-5-methoxystyrene

Base Information

• Chemical Name: 3-benzyloxy-5-methoxystyrene
• CAS No.: 296252-58-9
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.302
• Mol file: 296252-58-9.mol

Synonyms:3-benzyloxy-5-methoxystyrene

Chemical Property of 3-benzyloxy-5-methoxystyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-5-methoxystyrene

There total 3 articles about 3-benzyloxy-5-methoxystyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(benzyloxy)-5-methoxybenzaldehyde (50637-29-1) + Methylenetriphenylphosphorane (19493-09-5) → 3-benzyloxy-5-methoxystyrene (296252-58-9)

Guidance literature:

In tetrahydrofuran; at -78 - 25 ℃; for 2h;

DOI:10.1021/ja003835i

Reference yield:

3-hydroxy-5-methoxybenzaldehyde (57179-35-8) → 3-benzyloxy-5-methoxystyrene (296252-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 87 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja003835i

Reference yield:

benzyl bromide (100-39-0) → 3-benzyloxy-5-methoxystyrene (296252-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 87 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja003835i

upstream raw materials:

3-(benzyloxy)-5-methoxybenzaldehyde

Methylenetriphenylphosphorane

3-hydroxy-5-methoxybenzaldehyde

benzyl bromide

Downstream raw materials:

(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

(1S)-N-(trifluoroacetyl)-1-(5-hydroxy-3-methoxyphenyl)-2-(methoxyethoxy-methoxy)ethylamine

(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-(methoxyethoxymethoxy)ethylamine

((R)-1-{3-[3-((S)-1-Amino-2-hydroxy-ethyl)-5-methoxy-phenoxy]-4-methoxy-phenyl}-2-benzyloxy-ethyl)-carbamic acid tert-butyl ester