(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

Base Information

Chemical Name:(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine
CAS No.:331731-32-9
Molecular Formula:C₂₄H₂₅NO₅
Molecular Weight:407.466
Hs Code.:

Synonyms:(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

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Chemical Property of (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

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Technology Process of (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

There total 4 articles about (1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 91174-01-5
sodium [(benzyloxy)carbonyl]chloroamide

: 296252-58-9
3-benzyloxy-5-methoxystyrene

: 331731-32-9
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

Guidance literature:: With sodium hydroxide; tert-butylhypochlorite; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium dioxotetrahydroxoosmate(VI); In propan-1-ol; water; at 25 ℃; for 1h;
DOI:10.1021/ja003835i

Reference yield:

: 57179-35-8
3-hydroxy-5-methoxybenzaldehyde

: 331731-32-9
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 87 percent / tetrahydrofuran / 2 h / -78 - 25 °C

3: 78 percent / t-butyl hypochlorite; (DHQD)2PHAL; NaOH / K₂OsO₂(OH)4 / H₂O; propan-1-ol / 1 h / 25 °C

With sodium hydroxide; tert-butylhypochlorite; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; propan-1-ol; water; N,N-dimethyl-formamide; 3: Sharpless asymmetric aminohydroxylation;
DOI:10.1021/ja003835i

Reference yield:

: 50637-29-1
3-(benzyloxy)-5-methoxybenzaldehyde

: 331731-32-9
(1S)-N-benzyloxycarbonyl-1-(5-benzyloxy-3-methoxyphenyl)-2-hydroxyethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 2 h / -78 - 25 °C

2: 78 percent / t-butyl hypochlorite; (DHQD)2PHAL; NaOH / K₂OsO₂(OH)4 / H₂O; propan-1-ol / 1 h / 25 °C

With sodium hydroxide; tert-butylhypochlorite; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; propan-1-ol; water; 2: Sharpless asymmetric aminohydroxylation;
DOI:10.1021/ja003835i