5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine

Base Information

• Chemical Name: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine
• CAS No.: 146578-12-3
• Molecular Formula: C₄₄H₄₉N₅O₆Si
• Molecular Weight: 771.988

Synonyms:5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine

Chemical Property of 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine

Chemical Property:

Purity/Quality:

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Technology Process of 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine

There total 4 articles about 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine (146578-12-3)

Guidance literature:

With pyridine; 1H-imidazole; for 20h; Ambient temperature;

DOI:10.1016/S0040-4039(00)60176-4

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine (146578-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine

2: pyridine, imidazole / 20 h / Ambient temperature

With pyridine; 1H-imidazole;

DOI:10.1016/S0040-4039(00)60176-4

Reference yield:

N6-benzoyl-2'-deoxyadenosine (4546-72-9) → 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine (146578-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine

2: pyridine, imidazole / 20 h / Ambient temperature

With pyridine; 1H-imidazole;

DOI:10.1016/S0040-4039(00)60176-4

upstream raw materials:

tert-butyldimethylsilyl chloride

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

4,4'-dimethoxytrityl chloride

N₆-benzoyl-2'-deoxyadenosine

Downstream raw materials:

6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

(S_P)-N⁶-benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-adenoylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-methylphosphonate

(S_P)-5'-O-(4,4-dimethoxytrityl)thymidylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-methylphosphonate

C₅₈H₆₈N₁₀O₁₃P₂

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