Technology Process of 5'-aldehyde-2'-deoxy-6-N-benzoyl-3'-O-tertbutyldimethylsilyl adenosine
There total 4 articles about 5'-aldehyde-2'-deoxy-6-N-benzoyl-3'-O-tertbutyldimethylsilyl adenosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine;
With
dimethyl sulfoxide; dicyclohexyl-carbodiimide;
at 20 ℃;
for 1h;
With
oxalic acid;
In
ethyl acetate;
at 20 ℃;
for 1h;
DOI:10.1002/ejoc.200500398
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.20 g / p-toluenesulfonic acid hydrate / CHCl3; methanol / 0.5 h / 0 °C
2: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; pyridine; trifluoroacetic acid / toluene; dimethylsulfoxide / 2 h / 20 °C
With
pyridine; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
methanol; chloroform; dimethyl sulfoxide; toluene;
2: Moffatt oxidation;
DOI:10.1081/NCN-120037508
- Guidance literature:
-
Multi-step reaction with 3 steps
1: imidazole / dimethylformamide / 20 °C
2: 1.20 g / p-toluenesulfonic acid hydrate / CHCl3; methanol / 0.5 h / 0 °C
3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; pyridine; trifluoroacetic acid / toluene; dimethylsulfoxide / 2 h / 20 °C
With
pyridine; 1H-imidazole; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
methanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
3: Moffatt oxidation;
DOI:10.1081/NCN-120037508
