(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

Base Information

Chemical Name:(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]
CAS No.:1455213-61-2
Molecular Formula:C₄₀H₃₁BrN₂O₆S
Molecular Weight:747.666
Hs Code.:

Synonyms:(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

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Technology Process of (2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

There total 7 articles about (2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-tosylaminochalcone

: 71307-26-1
1-acetyl-3-[2-(4-bromo-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one

: 1455213-61-2
(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

Guidance literature:: 1-acetyl-3-[2-(4-bromo-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one; With C₃₂H₂₈F₆N₄O₃; In dichloromethane; at 20 ℃; for 0.166667h;

ortho-(tosylamino)chalcone; In dichloromethane; enantioselective reaction;
DOI:10.1039/c3cc44930k

Reference yield:

: 98-86-2
acetophenone

: 1455213-61-2
(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

Guidance literature:: Multi-step reaction with 4 steps

1: zirconium(IV) chloride / 1,2-dichloro-benzene / 60 °C

2: acetic acid; iron / ethanol / 70 °C

3: pyridine / Reflux

4: C₃₂H₂₈F₆N₄O₃ / dichloromethane / 0.17 h / 20 °C

With C₃₂H₂₈F₆N₄O₃; zirconium(IV) chloride; iron; acetic acid; In pyridine; ethanol; dichloromethane; 1,2-dichloro-benzene; 4: |Michael Addition;
DOI:10.1039/c3cc44930k

Reference yield:

: 108714-18-7
3-(2-aminophenyl)-1-phenylprop-2-en-1-one

: 1455213-61-2
(2’R,3’S,4’S)-1-acetyl-2’-(4-bromobenzoyl)-4’-(2-oxo-1-phenylethyl)-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline]

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / Reflux

2: C₃₂H₂₈F₆N₄O₃ / dichloromethane / 0.17 h / 20 °C

With C₃₂H₂₈F₆N₄O₃; In pyridine; dichloromethane; 2: |Michael Addition;
DOI:10.1039/c3cc44930k