tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Base Information

Chemical Name:tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate
CAS No.:1198054-83-9
Molecular Formula:C₂₁H₃₁ClN₂O₃
Molecular Weight:394.942
Hs Code.:

Synonyms:tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

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Chemical Property of tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Chemical Property:

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Technology Process of tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

There total 4 articles about tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 626-58-4
4-methylpiperidin

: 1032964-37-6
2-tert-butoxycarbonylamino-4-(2-chlorophenyl)butyric acid

: 1198054-83-9
tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 615-41-8
2-iodochlorobenzene

: 1198054-83-9
tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

2.1: zinc(II) iodide / diethyl ether / 0.25 h

2.2: 5 h / 50 °C

3.1: hydrogenchloride; water / 12 h / 100 °C

3.2: 2 h

3.3: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

With hydrogenchloride; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium diacetate; zinc(II) iodide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 157433-36-8
3-(2-chlorophenyl)propanal

: 1198054-83-9
tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) iodide / diethyl ether / 0.25 h

1.2: 5 h / 50 °C

2.1: hydrogenchloride; water / 12 h / 100 °C

2.2: 2 h

2.3: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc(II) iodide; In diethyl ether; dichloromethane;