4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

Base Information

Chemical Name:4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride
CAS No.:1198054-85-1
Molecular Formula:C₁₆H₂₃ClN₂O*ClH
Molecular Weight:331.285
Hs Code.:

Synonyms:4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

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Chemical Property of 4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

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Technology Process of 4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

There total 5 articles about 4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1198054-83-9
tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

: 1198054-85-1
4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h;

Reference yield:

: 615-41-8
2-iodochlorobenzene

: 1198054-85-1
4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

2.1: zinc(II) iodide / diethyl ether / 0.25 h

2.2: 5 h / 50 °C

3.1: hydrogenchloride; water / 12 h / 100 °C

3.2: 2 h

3.3: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

5.1: hydrogenchloride / 1,4-dioxane / 2 h

With hydrogenchloride; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium diacetate; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 157433-36-8
3-(2-chlorophenyl)propanal

: 1198054-85-1
4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) iodide / diethyl ether / 0.25 h

1.2: 5 h / 50 °C

2.1: hydrogenchloride; water / 12 h / 100 °C

2.2: 2 h

2.3: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: hydrogenchloride / 1,4-dioxane / 2 h

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane;