N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Base Information

Chemical Name:N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide
CAS No.:1198054-77-1
Molecular Formula:C₂₂H₂₇ClN₂O₃S
Molecular Weight:434.987
Hs Code.:

Synonyms:N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Chemical Property:

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Technology Process of N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

There total 6 articles about N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1198054-85-1
4-(2-chlorophenyl)-1-(4-methyl piperidin-1-yl)-1-oxobutan-2-amine hydrochloride

: 98-09-9
benzenesulfonyl chloride

: 1198054-77-1
N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Guidance literature:: With 4-methyl-morpholine; In 1,2-dichloro-ethane;

Reference yield:

: 615-41-8
2-iodochlorobenzene

: 1198054-77-1
N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

2.1: zinc(II) iodide / diethyl ether / 0.25 h

2.2: 5 h / 50 °C

3.1: hydrogenchloride; water / 12 h / 100 °C

3.2: 2 h

3.3: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

5.1: hydrogenchloride / 1,4-dioxane / 2 h

6.1: 4-methyl-morpholine / 1,2-dichloro-ethane

With 4-methyl-morpholine; hydrogenchloride; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium diacetate; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 157433-36-8
3-(2-chlorophenyl)propanal

: 1198054-77-1
N-{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) iodide / diethyl ether / 0.25 h

1.2: 5 h / 50 °C

2.1: hydrogenchloride; water / 12 h / 100 °C

2.2: 2 h

2.3: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: hydrogenchloride / 1,4-dioxane / 2 h

5.1: 4-methyl-morpholine / 1,2-dichloro-ethane

With 4-methyl-morpholine; hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane; 1,2-dichloro-ethane;