1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Base Information

Chemical Name:1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene
CAS No.:286967-47-3
Molecular Formula:C₁₈H₂₈OSi
Molecular Weight:289.497
Hs Code.:

Synonyms:1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Suppliers and Price of 1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

There total 11 articles about 1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 286967-48-4
(S)-(-)-2-d₁-phenethyl bromide

: 75-77-4
chloro-trimethyl-silane

: 54307-74-3,15466-88-3
(R)-5-methyl-cyclohex-2-enone

: 286967-47-3
1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Guidance literature:: (S)-(-)-2-d₁-phenethyl bromide; With magnesium;

chloro-trimethyl-silane; (R)-5-methyl-cyclohex-2-enone; With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;
DOI:10.1021/ja000239f

Reference yield:

: S-(-)-2-d₁-phenylethanol methanesulfonate

: 286967-47-3
1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / LiBr / dimethylformamide / 1 h / 70 °C / Heating

2.1: Mg

2.2: 70 percent / CuBr(Me₂S); HMPA / tetrahydrofuran / 3 h / -78 °C

With magnesium; lithium bromide; In N,N-dimethyl-formamide; 1.1: Bromination / 2.1: Grignard reaction / 2.2: Addition;
DOI:10.1021/ja000239f

Reference yield:

: 17199-29-0
(S)-Mandelic acid

: 286967-47-3
1-trimethylsilyloxy-3(S)-[2-deutero-2(S)-phenethyl]-5(R)-methyl-1-cyclohexene

Guidance literature:: Multi-step reaction with 8 steps

1.1: CH₃C(OCH₃)2CH₃; H₂SO₄

2.1: LiAlH₄ / 1,2-dimethoxy-ethane / 12 h / 20 °C

3.1: H₂SO₄ / 20 - 50 °C / Heating

4.1: chlorotrimethylsilane / CH₂Cl₂ / 2 h / 0 °C

5.1: 83 percent / LiAlD₄ / tetrahydrofuran / 4 h / 20 °C

6.1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

7.1: 80 percent / LiBr / dimethylformamide / 1 h / 70 °C / Heating

8.1: Mg

8.2: 70 percent / CuBr(Me₂S); HMPA / tetrahydrofuran / 3 h / -78 °C

With lithium aluminium tetrahydride; chloro-trimethyl-silane; lithium aluminium deuteride; sulfuric acid; magnesium; triethylamine; 2,2-dimethoxy-propane; lithium bromide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 1.1: Methylation / 2.1: Elimination / 3.1: Addition / 4.1: Elimination / 5.1: Reduction / 6.1: Addition / 7.1: Bromination / 8.1: Grignard reaction / 8.2: Addition;
DOI:10.1021/ja000239f