(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453853-26-3
Molecular Formula:C₂₉H₃₃ClFN₅O₂Si
Molecular Weight:566.15
Hs Code.:

Synonyms:(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 10 articles about (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 18437-58-6
3-methyl-4-pyridinamine

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453853-26-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: 3-methyl-4-pyridinamine; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h;

(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453853-26-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

2.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

5.2: 30 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

7.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

7.2: 0.5 h / -78 °C

With 1H-imidazole; AD-mix-β; tert.-butyl lithium; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; mineral oil; tert-butyl alcohol; 1.1: |Wittig Rearrangement;

Reference yield:

: 1263414-46-5
1-chloro-2-fluoro-4-vinylbenzene

: 1453853-26-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyridin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 30 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

6.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

6.2: 0.5 h / -78 °C

With 1H-imidazole; AD-mix-β; tert.-butyl lithium; potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;