3-hydroxy-4-methoxyformanilide

Base Information

• Chemical Name: 3-hydroxy-4-methoxyformanilide
• CAS No.: 862794-16-9
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Mol file: 862794-16-9.mol

Synonyms:3-hydroxy-4-methoxyformanilide

Chemical Property of 3-hydroxy-4-methoxyformanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-hydroxy-4-methoxyformanilide

There total 1 articles about 3-hydroxy-4-methoxyformanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-amino-2-methoxyphenol (1687-53-2) + formic acid ethyl ester (109-94-4) → 3-hydroxy-4-methoxyformanilide (862794-16-9)

Guidance literature:

With formic acid; for 48h; Heating;

DOI:10.1016/j.tet.2005.05.055

Reference yield: 82.0%

3-hydroxy-4-methoxyformanilide (862794-16-9) + benzyl chloride (100-44-7) → 3-benzyloxy-4-methoxyformanilide (862794-18-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 8h;

DOI:10.1016/j.tet.2005.05.055

Reference yield:

3-hydroxy-4-methoxyformanilide (862794-16-9) → N-methyl-2-bromo-5-benzyloxy-4-methoxyaniline (862794-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 8 h / 120 °C

2: 86 percent / N-bromoacetamide / tetrahydrofuran / 0 °C

3: 91 percent / BH₃*THF / tetrahydrofuran / 0.5 h / Heating

With borane-THF; potassium carbonate; N-bromoacetamide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.05.055

upstream raw materials:

5-amino-2-methoxyphenol

formic acid ethyl ester

Downstream raw materials:

3-benzyloxy-4-methoxyformanilide

N-methyl-2-bromo-5-benzyloxy-4-methoxyaniline

N-(5-benzyloxy-2-bromo-4-methoxy-phenyl)-formamide

N-[3-(4-hydroxyphenyl)propionyl]-N-methyl-2-bromo-5-hydroxy-4-methoxyaniline

Refernces