[2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane

Base Information

• Chemical Name: [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane
• CAS No.: 117924-17-1
• Molecular Formula: C₁₉H₂₇O₂PSi
• Molecular Weight: 346.481
• Mol file: 117924-17-1.mol

Synonyms:[2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane

Chemical Property of [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane

There total 2 articles about [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloro-trimethyl-silane (75-77-4) + (2-hydroxy-2-methylpropyl)diphenylphosphine oxide (35078-75-2) → [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane (117924-17-1)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1055/s-1988-27466

Reference yield:

diphenyl(methyl)phosphine oxide (2129-89-7) → [2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane (117924-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) butyllithium / 1.) hexane, Et₂O, 0 deg C, 2 h, 2.) room temp., 2 h, then reflux, 1h

2: 82 percent / pyridine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; n-butyllithium; In dichloromethane;

DOI:10.1055/s-1988-27466

Reference yield: 75.0%

[2-(Diphenyl-phosphinoyl)-1,1-dimethyl-ethoxy]-trimethyl-silane (117924-17-1) → 1-(diphenyl-phosphinoyl)-2-methylprop-2-ene (4455-75-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 70 ℃; for 2h;

DOI:10.1055/s-1988-27466

upstream raw materials:

chloro-trimethyl-silane

(2-hydroxy-2-methylpropyl)diphenylphosphine oxide

diphenyl(methyl)phosphine oxide

Downstream raw materials:

1-(diphenyl-phosphinoyl)-2-methylprop-2-ene