(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

Base Information

Chemical Name:(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane
CAS No.:868668-26-2
Molecular Formula:C₂₅H₄₄O₄Si
Molecular Weight:436.707
Hs Code.:

Synonyms:(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

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Chemical Property of (2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

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Technology Process of (2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

There total 4 articles about (2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 868668-25-1
(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

: 556-56-9
allyl iodid

: 868668-26-2
(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

Guidance literature:: (2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol; With 15-crown-5; sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

allyl iodid; In tetrahydrofuran; at 20 ℃;
DOI:10.1248/cpb.53.989

Reference yield:

: 868668-36-4
(4S,6R)-7-(p-methoxybenzyloxy)-6-methyl-1,4-heptanediol

: 868668-26-2
(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / imidazole / dimethylformamide / 20 °C

2.1: NaH; 15-crown-5 / tetrahydrofuran / 0.5 h / 0 °C

2.2: 96 percent / tetrahydrofuran / 20 °C

With 1H-imidazole; 15-crown-5; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.989

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 868668-26-2
(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / imidazole / dimethylformamide / 20 °C

2.1: NaH; 15-crown-5 / tetrahydrofuran / 0.5 h / 0 °C

2.2: 96 percent / tetrahydrofuran / 20 °C

With 1H-imidazole; 15-crown-5; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.989