(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

Base Information

Chemical Name:(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol
CAS No.:868668-25-1
Molecular Formula:C₂₂H₄₀O₄Si
Molecular Weight:396.643
Hs Code.:

Synonyms:(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

Chemical Property:

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Technology Process of (2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

There total 2 articles about (2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 868668-36-4
(4S,6R)-7-(p-methoxybenzyloxy)-6-methyl-1,4-heptanediol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 868668-25-1
(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1248/cpb.53.989

Reference yield:

: 259198-98-6
(4S,6R)-7-(p-methoxybenzyloxy)-6-methylhept-1-en-4-ol

: 868668-25-1
(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

Guidance literature:: Multi-step reaction with 2 steps

1.1: BH₃ / tetrahydrofuran / 20 °C

1.2: 92 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 20 °C

2.1: 93 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; borane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.989

Reference yield: 96.0%

: 868668-25-1
(2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol

: 556-56-9
allyl iodid

: 868668-26-2
(2R,4S)-4-allyloxy-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylheptane

Guidance literature:: (2R,4S)-7-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methyl-4-heptanediol; With 15-crown-5; sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

allyl iodid; In tetrahydrofuran; at 20 ℃;
DOI:10.1248/cpb.53.989