(R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate

Base Information

• Chemical Name: (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate
• CAS No.: 1187465-77-5
• Molecular Formula: C₂₃H₃₂ClN₃O₄S
• Molecular Weight: 482.044
• Mol file: 1187465-77-5.mol

Synonyms:(R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate

Chemical Property of (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate

There total 4 articles about (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-tert-butyl-1,3-thiazol-2-amine (299417-31-5) + (R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine (129319-91-1) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate (1187465-77-5)

Guidance literature:

5-tert-butyl-1,3-thiazol-2-amine; (R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine; at 85 ℃; for 24h;

2-methoxy-5-chlorobenzoyl chloride; In dichloromethane; N,N-dimethyl-formamide; for 24h;

Reference yield:

3,3-dimethylbutyrylaldehyde (2987-16-8) → (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate (1187465-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyrrolidine; toluene-4-sulfonic acid / cyclohexane / 3 h / Reflux

1.2: 0 - 20 °C

2.1: 24 h / 85 °C

2.2: 24 h

With pyrrolidine; toluene-4-sulfonic acid; In cyclohexane;

Reference yield:

5-chloro-2-methoxybenzoic acid (3438-16-2) → (R,Z)-tert-butyl 1-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)propan-2-ylcarbamate (1187465-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 2 h / Reflux

2.1: 24 h / 85 °C

2.2: 24 h

With thionyl chloride; In toluene;

upstream raw materials:

5-tert-butyl-1,3-thiazol-2-amine

(R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine

2-methoxy-5-chlorobenzoyl chloride

3,3-dimethylbutyrylaldehyde

Downstream raw materials:

N-[(2Z)-3-[(2R)-2-aminopropyl]-5-tert-butyl-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide