[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

Base Information

Chemical Name:[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone
CAS No.:1441141-99-6
Molecular Formula:C₂₂H₂₀ClF₃N₄O
Molecular Weight:448.875
Hs Code.:

Synonyms:[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

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Chemical Property of [2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

Chemical Property:

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Technology Process of [2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

There total 6 articles about [2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441141-93-0
[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]-[2-nitro-5-(1-piperidyl)phenyl]methanone

: 1441141-99-6
[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

Guidance literature:: With ammonium chloride; zinc; In methanol; for 2h; Reflux;

Reference yield:

: 1441141-71-4
1-[4-chloro-3-(trifluoromethyl)phenyl]-4-iodopyrazole

: 1441141-99-6
[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

1.2: 2 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: 0.33 h / 90 °C

4.1: ammonium chloride; zinc / methanol / 2 h / Reflux

With isopropylmagnesium chloride; ammonium chloride; Dess-Martin periodane; zinc; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 445-01-2
5-bromo-2-chlorobenzotrifluoride

: 1441141-99-6
[2-amino-5-(1-piperidyl) phenyl]-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium carbonate; sodium L-ascorbate / dimethyl sulfoxide / 52 h / 100 - 140 °C / Inert atmosphere

2.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

3.2: 2 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: 0.33 h / 90 °C

6.1: ammonium chloride; zinc / methanol / 2 h / Reflux

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; N-iodo-succinimide; copper(l) iodide; isopropylmagnesium chloride; sodium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; sodium L-ascorbate; zinc; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;