3-(3-cyclohexenyl)-2,2-dichloropropanamide

Base Information

• Chemical Name: 3-(3-cyclohexenyl)-2,2-dichloropropanamide
• CAS No.: 115141-15-6
• Molecular Formula: C₉H₁₃Cl₂NO
• Molecular Weight: 222.114
• Mol file: 115141-15-6.mol

Synonyms:3-(3-cyclohexenyl)-2,2-dichloropropanamide

Chemical Property of 3-(3-cyclohexenyl)-2,2-dichloropropanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(3-cyclohexenyl)-2,2-dichloropropanamide

There total 2 articles about 3-(3-cyclohexenyl)-2,2-dichloropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate (126497-20-9) → 3-(3-cyclohexenyl)-2,2-dichloropropanamide (115141-15-6)

Guidance literature:

With ammonium chloride; trimethylaluminum; In dichloromethane; Heating;

DOI:10.1021/ja00224a043

Reference yield:

(3-cyclohexenyl)-iodomethane (119867-11-7) → 3-(3-cyclohexenyl)-2,2-dichloropropanamide (115141-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -55 to -60 deg C; 2.) THF, HMPA, -55 to -60 deg C, 1 h, -30 deg C, 3 h

2: 76 percent / trimethyl aluminum, ammonium chloride / CH₂Cl₂ / Heating

With ammonium chloride; trimethylaluminum; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/ja00224a043

Reference yield: 83.0%

3-(3-cyclohexenyl)-2,2-dichloropropanamide (115141-15-6) → 3-(3-cyclohexenyl)-2,2-dichloropropionitrile (115119-93-2)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In tetrahydrofuran; 0 deg C, 1 h, room temp., 3h;

DOI:10.1021/ja00224a043

upstream raw materials:

ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate

(3-cyclohexenyl)-iodomethane

Downstream raw materials:

3-(3-cyclohexenyl)-2,2-dichloropropionitrile