ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate

Base Information

• Chemical Name: ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate
• CAS No.: 126497-20-9
• Molecular Formula: C₁₁H₁₆Cl₂O₂
• Molecular Weight: 251.153
• Mol file: 126497-20-9.mol

Synonyms:ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate

Chemical Property of ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate

There total 1 articles about ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-cyclohexenyl)-iodomethane (119867-11-7) + ethyl 1,1-dichloroacetate (535-15-9) → ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate (126497-20-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -55 to -60 deg C; 2.) THF, HMPA, -55 to -60 deg C, 1 h, -30 deg C, 3 h;

DOI:10.1021/ja00224a043

Reference yield: 76.0%

ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate (126497-20-9) → 3-(3-cyclohexenyl)-2,2-dichloropropanamide (115141-15-6)

Guidance literature:

With ammonium chloride; trimethylaluminum; In dichloromethane; Heating;

DOI:10.1021/ja00224a043

Reference yield:

ethyl 3-(3-cyclohexenyl)-2,2-dichloropropanoate (126497-20-9) → 3-(3-cyclohexenyl)-2,2-dichloropropionitrile (115119-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / trimethyl aluminum, ammonium chloride / CH₂Cl₂ / Heating

2: 83 percent / pyridine, trifluoroacetic anhydride / tetrahydrofuran / 0 deg C, 1 h, room temp., 3h

With pyridine; ammonium chloride; trimethylaluminum; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00224a043

upstream raw materials:

(3-cyclohexenyl)-iodomethane

ethyl 1,1-dichloroacetate

Downstream raw materials:

3-(3-cyclohexenyl)-2,2-dichloropropanamide

3-(3-cyclohexenyl)-2,2-dichloropropionitrile