cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

Base Information

Chemical Name:cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate
CAS No.:1446193-36-7
Molecular Formula:C₂₂H₂₅N₅O₆S
Molecular Weight:487.536
Hs Code.:

Synonyms:cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

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Chemical Property of cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

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Technology Process of cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

There total 4 articles about cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 38377-38-7
4-fluorophenyl chloroformate

: 1446194-04-2
3-[(Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(3-methoxyphenyl)methyl]-2-methyl-1,2,4-oxadiazol-5(2H)-one

: 108-93-0
cyclohexanol

: 1446193-36-7
cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

Guidance literature:: 4-fluorophenyl chloroformate; 3-[(Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(3-methoxyphenyl)methyl]-2-methyl-1,2,4-oxadiazol-5(2H)-one; With pyridine; In acetonitrile; at 20 ℃; for 2h;

cyclohexanol; In acetonitrile; for 15h; Reflux;

Reference yield:

: 1446194-13-3
(2Z)-(hydroxyimino)(3-methoxyphenyl)acetonitrile

: 1446193-36-7
cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium iodide; caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 8 h / 20 °C

2.1: potassium carbonate / isopropyl alcohol; water / 2 h / 80 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0 °C

4.1: pyridine / acetonitrile / 2 h / 20 °C

4.2: 15 h / Reflux

With pyridine; potassium carbonate; caesium carbonate; triethylamine; potassium iodide; In water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1446194-09-7
(2Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(3-methoxyphenyl)acetonitrile

: 1446193-36-7
cyclohexyl {4-[({[(Z)-(3-methoxyphenyl)(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / isopropyl alcohol; water / 2 h / 80 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0 °C

3.1: pyridine / acetonitrile / 2 h / 20 °C

3.2: 15 h / Reflux

With pyridine; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;