methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate

Base Information

• Chemical Name: methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate
• CAS No.: 189177-71-7
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.243
• Mol file: 189177-71-7.mol

Synonyms:methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate

Chemical Property of methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate

There total 6 articles about methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2E)-2-[2-[(1,3-dioxoisoindolin-2-yl)oxymethyl]phenyl]-2-methoxyiminoacetate (156581-14-5) → methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate (189177-71-7)

Guidance literature:

With hydrazine; In methanol; at 20 ℃; for 2h;

Reference yield:

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate (133409-72-0) → methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate (189177-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / dimethylformamide / 0.33 h / 20 °C

1.2: 91 percent / dimethylformamide / 20 °C

2.1: 89 percent / hydrazine monohydrate / methanol / 2 h / 20 °C

With sodium hydroxide; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jf060074f

Reference yield:

methyl (E)-2-hydroxyimino-2-o-tolylacetate (178240-01-2) → methyl (E)-α-(methoxyimino)-2-(aminoxymethyl)benzeneacetate (189177-71-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 91 percent / dimethylformamide / 12 h / 20 °C

2.1: 81 percent / N-bromosuccinimide; 2,2'-azo-bisisobutyronitrile / CCl₄ / 10 h / Heating

3.1: NaOH / dimethylformamide / 0.33 h / 20 °C

3.2: 91 percent / dimethylformamide / 20 °C

4.1: 89 percent / hydrazine monohydrate / methanol / 2 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; hydrazine hydrate; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jf060074f

upstream raw materials:

methyl (2E)-2-[2-[(1,3-dioxoisoindolin-2-yl)oxymethyl]phenyl]-2-methoxyiminoacetate

methyl (E)-2-hydroxyimino-2-o-tolylacetate

methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate

o-toluene-diazonium chloride