(2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol

Base Information

• Chemical Name: (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol
• CAS No.: 171622-74-5
• Molecular Formula: C₂₄H₃₆O₄Si
• Molecular Weight: 416.633
• Mol file: 171622-74-5.mol

Synonyms:(2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol

Chemical Property of (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol

There total 17 articles about (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol (113350-84-8) → (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol (171622-74-5)

Guidance literature:

With n-butyllithium;

DOI:10.1016/j.jfluchem.2011.02.015

Reference yield:

benzyl bromide (100-39-0) → (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol (171622-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride

2: lithium aluminium tetrahydride

3: n-butyllithium

With lithium aluminium tetrahydride; n-butyllithium; sodium hydride;

DOI:10.1016/j.jfluchem.2011.02.015

Reference yield:

(2S,3S)-diethyl 2,3-bis(phenylmethoxy)succinate (113321-58-7) → (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol (171622-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride

2: n-butyllithium

With lithium aluminium tetrahydride; n-butyllithium;

DOI:10.1016/j.jfluchem.2011.02.015

upstream raw materials:

((2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-ynyloxy)-tert-butyl-dimethyl-silane

tert-butyldimethylsilyl chloride

(2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol

(2R,3R)-2,3-Bis(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-6-methyl-4-heptene

Downstream raw materials:

(2S,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butanal

(4R,5R)-4,5-Bis-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-hex-1-yn-3-ol

phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyl ester

phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester