C₂₃H₁₈BrF₃O₄

Base Information

Chemical Name:C₂₃H₁₈BrF₃O₄
CAS No.:1335557-41-9
Molecular Formula:C₂₃H₁₈BrF₃O₄
Molecular Weight:495.293
Hs Code.:

C<sub>23</sub>H<sub>18</sub>BrF<sub>3</sub>O<sub>4</sub>

Synonyms:C₂₃H₁₈BrF₃O₄

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Chemical Property of C₂₃H₁₈BrF₃O₄

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Technology Process of C₂₃H₁₈BrF₃O₄

There total 13 articles about C₂₃H₁₈BrF₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335557-40-8
C₂₃H₁₉F₃O₄

: 1335557-41-9
C₂₃H₁₈BrF₃O₄

Guidance literature:: C₂₃H₁₉F₃O₄; With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; at 20 ℃; for 21h;

With bromine; sodium acetate; acetic acid; for 1h;

With benzyl bromide; potassium carbonate; In acetone; at 50 ℃; for 6h;

Reference yield:

: 877149-05-8
4-bromo-2-methoxy-6-methyl-benzonitrile

: 1335557-41-9
C₂₃H₁₈BrF₃O₄

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

1.2: 0 - 20 °C

2.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

2.2: pH 1

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 19 h / Inert atmosphere; Reflux

6.1: ozone; oxygen / dichloromethane / -78 °C

6.2: -78 - 25 °C

7.1: bromine; acetic acid / 1 h / 20 °C

8.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

10.1: copper(l) iodide / N,N-dimethyl-formamide / 20 h / 100 °C / Sealed

11.1: sodium tetrahydroborate; methanol / 2 h

12.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; methanol / 21 h / 20 °C

12.2: 1 h

12.3: 6 h / 50 °C

With methanol; dmap; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; copper(l) iodide; 2-methyl-but-2-ene; oxalyl dichloride; water; hydrogen; bromine; oxygen; boron tribromide; diisobutylaluminium hydride; potassium carbonate; ozone; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 348169-39-1
4-bromo-2-methoxy-6-methyl-phenylamine

: 1335557-41-9
C₂₃H₁₈BrF₃O₄

Guidance literature:: Multi-step reaction with 13 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.3: 4 h / 0 - 50 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

2.2: 0 - 20 °C

3.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

3.2: pH 1

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

5.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 19 h / Inert atmosphere; Reflux

7.1: ozone; oxygen / dichloromethane / -78 °C

7.2: -78 - 25 °C

8.1: bromine; acetic acid / 1 h / 20 °C

9.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

11.1: copper(l) iodide / N,N-dimethyl-formamide / 20 h / 100 °C / Sealed

12.1: sodium tetrahydroborate; methanol / 2 h

13.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; methanol / 21 h / 20 °C

13.2: 1 h

13.3: 6 h / 50 °C

With hydrogenchloride; methanol; dmap; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; copper(l) iodide; 2-methyl-but-2-ene; oxalyl dichloride; water; hydrogen; bromine; oxygen; boron tribromide; diisobutylaluminium hydride; potassium carbonate; ozone; acetic acid; triethylamine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;