(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

Base Information

Chemical Name:(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide
CAS No.:866835-66-7
Molecular Formula:C₄₀H₃₆N₄O₈
Molecular Weight:700.748
Hs Code.:

Synonyms:(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

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Chemical Property of (E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

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Technology Process of (E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

There total 5 articles about (E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 18942-49-9
Boc-D-Phe-OH

: 605636-80-4
(E)-N-(4-amino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amide

: 866835-66-7
(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

Guidance literature:: With trichlorophosphate; In pyridine; at -15 ℃; for 0.5h;

Reference yield:

: 1775-95-7
2-amino-5-nitrobenzophenone

: 866835-66-7
(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 2 h / 0 °C

2: SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

3: toluene; dioxane / 2 h / Heating

4: aq. K₂CO₃ / dioxane / 3 h / Heating

5: POCl₃; pyridine / 0.5 h / 0 °C

With pyridine; potassium carbonate; tin(ll) chloride; trichlorophosphate; In 1,4-dioxane; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(03)00179-3

Reference yield:

: 357436-78-3
N-(4-amino-2-benzoylphenyl)-trifluoroacetic acid amide

: 866835-66-7
(E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene; dioxane / 2 h / Heating

2: aq. K₂CO₃ / dioxane / 3 h / Heating

3: POCl₃; pyridine / 0.5 h / 0 °C

With pyridine; potassium carbonate; trichlorophosphate; In 1,4-dioxane; toluene;
DOI:10.1016/S0960-894X(03)00179-3