1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

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Chemical Name:1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate
CAS No.:1394001-74-1
Molecular Formula:C₂₈H₃₃FN₄O₄
Molecular Weight:508.593
Hs Code.:

Synonyms:1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

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Chemical Property of 1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

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Technology Process of 1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

There total 3 articles about 1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1269407-87-5
4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

: 172843-97-9
4-(Boc-amino)tetrahydropyran-4-carboxylic acid

: 1394001-74-1
1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 0.416667h;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1394001-74-1
1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0.42 h / 20 °C

With hydrogenchloride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1394001-74-1
1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0.42 h / 20 °C

With hydrogenchloride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki Coupling;